Genital herpes are a pain. Genital herpes can affect the genitals, upper thighs, buttocks, or hips. Symptoms come on once a year to every few months and include: Clear blisters than break open into painful ulcers Skin irritation, cuts, or fissures Vaginal irritation or fissures If you’ve got a herpes outbreak right now you’ll want treatment that helps with your immediate symptoms. These genital herpes medications last from 1 to 5 days. If you don’t have an outbreak now but want to prevent future outbreaks and decrease the chance of giving herpes to your partner, you should consider daily preventative treatment - so called ‘suppression’.